Using single photon emission computed tomography (SPECT), researchers in France were able to detect functional abnormalities in certain regions in the brains of patients diagnosed with fibromyalgia, reinforcing the idea that symptoms of the disorder are related to a dysfunction in those parts of the brain where pain is processed.
Clinical Correlate of Brain SPECT Perfusion Abnormalities in Fibromyalgia
E Guedj, S Cammilleri, J Niboyet, P Dupont et al
The purpose of this study was to investigate the specific clinical correlate of brain SPECT perfusion abnormalities reported in fibromyalgia.
Methods:We performed a whole-brain voxel-based correlation analysis involving regional cerebral blood flow and various parameters related to pain (Visual Analog Scale, Tubingen Pain Behavior Scale, and Questionnaire Douleur de Saint-Antoine Scale), disability (Fibromyalgia Impact Questionnaire
[FIQ]), and anxiety and depression status (Hospital Anxiety and Depression scale) in 20 patients with fibromyalgia (P voxel, 0.005). Ten healthy control women were also included, in order to determine areas of significant hypo- and hyperperfusions in patients.
Results: FIQ total score was positively correlated with bilateral parietal perfusion, including postcentral cortex. These clusters of correlation were included in the areas of significant hyperperfusion. FIQ total score was also negatively correlated with perfusion of a left anterior temporal cluster, included in the areas of significant hypoperfusions. No other clinical correlation was observed with regional cerebral blood flow.
Conclusion: These results show that brain perfusion abnormalities in patients with fibromyalgia are correlated with the clinical severity of the disease.
The Journal of Nuclear Medicine 2008; 49:1798–1803
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DOI: 10.2967/jnumed.108.053264
Filed under: Fibromyalgia, disability, imaging
